Signaling via the mTOR pathway in cancer is modulated by the Golgi-localized oncoprotein GOLPH3 [122], which also performs sorting of specific glycosyl transferases of GSL synthesis into vesicles for intra-Golgi retro-transport, enabling the cisternal maturation mechanism and controlling the sub-Golgi enzyme localization and its lysosomal degradation rate [123]. This evidence concerns the gene MTOR and cancer.