Genetic association model analysis showed that cohorts who were carrying DROSHA A/A were at higher risk of developing BC under the recessive model (OR = 6.3, 95%CI = 1.23–8.36, p < 0.001) and homozygote comparison model (OR = 3.2, 95%CI = 1.23–9.36, p < 0.001). This evidence concerns the gene DROSHA and breast cancer.