HMOX1 and diabetic kidney disease: Wang et al. [121] induced a diabetic kidney disease (DKD) rat model with intravenous injection of streptozotocin and found that after TPGs treatment, various indexes of the DKD model decreased, including the kidney index, 24 h urinary albumin content, fasting blood glucose (FBG), serum creatinine (Scr), and blood urea nitrogen (BUN), as well as the expression levels of MDA activity, α-SMA, and FN protein in kidney tissue, while the levels of SOD, nuclear Nrf2, and HO-1 protein in the kidney tissue increased.