The traits of neurodegenerative diseases encompass neuronal dysfunction and degeneration [3], impaired synaptic plasticity, and proteinopathies involving misfolded amyloid-β (Aβ) and tau proteins in Alzheimer’s disease (AD), as well as α-synuclein aggregates in Parkinson’s disease (PD) [4,5]. Here, MAPT is linked to Alzheimer disease.