The presence of this strong CD20 is atypical, while HLA-B*49:01:01 was mentioned earlier because it is associated with CD22 in atypical forms of CLL, and HLA-DRB1*11:04:01, although nonspecific for CLL, is associated with the occurrence of complications. This evidence concerns the gene HLA-DRB1 and B-cell chronic lymphocytic leukemia.