The fact that the HLA-DRB1*14:01:01, HLA-DQB1*05:03:01 and HLA-DQA1*01:04:01 alleles are associated with a strong expression of CD81, which is not exactly specific for CLL, indicates a form of severity, especially in the context of WBC values up to 18,500/L. Here, CD81 is linked to B-cell chronic lymphocytic leukemia.