While HLA-DQA1*05:01:01 is predominantly recognized for its involvement in the development of Celiac disease [14,69,], previous studies, such as the one conducted by Gragert et al. [19] have highlighted the importance of HLA-C*07:01 in CLL, while our team mentioned and HLA-DQA1*01:02:01 for its tendency to approach the limit of statistical significance in CLL [23]. The gene discussed is HLA-C; the disease is B-cell chronic lymphocytic leukemia.