TNFAIP6 and ischemic stroke: Interestingly, by blocking the pentraxin-3/fibroblast growth factor-2 interaction, TSG-6 was found to hamper vascular inflammation and endothelial dysfunction [42], two pivotal pathobiological mechanisms implicated in the progression of ischemic stroke and relevant co-morbidities (e.g., COVID-19), as well as in the development of long-term consequences (e.g., cognitive impairment) [43,44,45,46,47].