BDNF and central nervous system cancer: Researchers have studied the brain-derived neurotrophic factor (BDNF/abrineurin/neurotrophin), which plays a role in differentiation and apoptosis by the overexpression of transmembrane tyrosine kinase B (TrkB) in gliomas [53,54], and NLGN3 (neuroligin 3), a cell-adhesion molecule [12], but further research is necessary to unveil possible therapeutic strategies.