EGFR and glioblastoma: Another growth factor is represented by the epidermal growth factor receptor (EGFR), an oncogenic tyrosine-kinase receptor formed by an extracellular domain (ECD), a transmembrane domain (TMD), an intracellular juxta membrane domain (JMD), a tyrosine kinase, and a C-terminal end that was one of the first oncogenes identified in the GBM [76].