The phosphoinositide 3-kinase-AKT (PI3k-AKT) pathway is one of the most commonly altered pathways in all cancers; the homeostatic balance of cell division and programmed cell death is generally disturbed in tumorigenesis, and downstream effectors of the PI3k-AKT pathway play an essential role in this process [16]. The gene discussed is AKT1; the disease is cancer.