SSTR2 and major depressive disorder: Feeding and drinking behaviors are also associated with SSTR2 [51,106] and the reduction in stress-induced or stress-related endocrine functions of the CNS and the pituitary gland [52,60]; an anti-depression role has also been proposed, associated with activation of SSTR2 and SSTR3, which in turn modulates serotonin release, although the precise mechanisms are still uncertain [47,48].