BAX and melanoma: -It plays a significant role in initiation of the processes of programmed cell death in MM cells.-It can be activated by IFN-beta (could be a potential predictor of IFN-beta treatment efficacy).-It initiates mitochondrial-dependent apoptosis through direct or indirect activation of Bax protein.-It may play a key role in the apoptotic response of melanoma cells to certain chemotherapeutic agents.