-Activated caspase-3 is expressed in non-apoptotic melanoma cells and contributes to melanoma migration, invasion, metastasis, and VM formation.-It mediates the mechanism of the growth of living tumor cells after cytotoxic treatment in dying melanoma cells.-The induction of IRAK-M expression using genetic or epigenetic modifications initiates apoptosis. This evidence concerns the gene IRAK3 and melanoma.