Kalai et al. found that IFN-gamma stimulates caspase-12, but in IFN-γ-treated melanoma cells, increased expression of inflammatory caspases (caspase-1, caspase-11, and caspase-12) and decreased expression of apoptotic caspases (caspase-3 and caspase-9) suggest an alternative apoptotic cascade. This evidence concerns the gene CASP12 and melanoma.