Research has been conducted on several cell-signaling pathways which control mitophagy in systemic lupus erythematosus, such as mTOR Complex 1, 5′ AMP-activated protein kinase, cryopyrin, inflammasome, and cGAS–TMEM173 pathways [38,39]. The gene discussed is NLRP3; the disease is systemic lupus erythematosus.