According to experiments on rat models of osteoporosis, PEMF stimulates bone regeneration by increasing the remodeling process through the stimulation of osteoblast and osteoclast cell proliferation and function enhancement, such as ALP elevation, RANK/RANKL/OPG regulation, and Wnt signaling [17,18,19,20]. This evidence concerns the gene TNFSF11 and osteoporosis.