Moreover, Wang et al. (2014) [28] analyzed the effects of Chinese propolis extract and found that its administration promoted a significant protective effect in attenuating histopathological changes and suppressing the secretion of inflammatory cytokines stimulated by LPS, such as IL-6 and TNF-α, in mice with endotoxemia, revealing potent anti-inflammatory activity of Chinese propolis. This evidence concerns the gene IL6 and serum lipopolysaccharide activity.