Additionally, c-Met promoter activity was notably present in lung cancer cell lines, whereas it was absent in normal cells, as shown in Figure 2A. Leveraging the elevated c-Met expression in cancer cells, we developed an oncolytic adenovirus named Ad.What, which features a c-Met promoter-driven E1a gene, depicted in Figure 1A. In our research on the cytopathic effects of Ad.What, we found that this adenovirus causes significantly higher cytopathic effects in A549 lung cancer cells than in other cancer cell types while exhibiting minimal effects on normal human cells. The gene discussed is DHTKD1; the disease is cancer.