Under RA conditions, all three subpopulations upregulated CXCL1, CXCL2, CXCL3, CCL4, CCL4L2, IL-1β, TNFAIP3, ICAM1, PLAU and TNF in the NF-κB signalling pathway to varying extents [45]. This evidence concerns the gene IL1B and rheumatoid arthritis.