Significantly higher ratios were also found in the ratios of CD28/CD86 and PD-L1/CD86 between cSCC and BCC in both the invasive front (p < 0.001; Figure 3c,g) and the core (p < 0.001; Figure 3d,h) in favor of cSCC. The gene discussed is CD28; the disease is skin basal cell carcinoma.