IL-13Rα2 does bind to IL-13 more readily than IL-13Rα1 and it is therefore hypothesized that GBM tumors potentially use IL-13Rα2 expression to bind up available IL-13 and prevent immune responses to the tumor cells by stimulating TGF-β production [83,121,124]. This evidence concerns the gene IL13RA2 and glioblastoma.