The functional clustering of these genes revealed six biologically relevant clusters, of which we focused on the four clusters (Cluster 2 and 3, and Cluster 4 and 5) related to obesity and feeding behavior, axon guidance and neurite outgrowth, and neuroinflammation based on their FDR values and significant overlap with the biological functions of SIK2 based on its knockout mice and modified cell lines, respectively. The gene discussed is SIK2; the disease is obesity disorder.