MBP and myeloid sarcoma: The most commonly used model for studying autoimmune-mediated myelin degradation in MS is EAE, in which the disease can be induced (active EAE) in susceptible animals by immunization with one of the myelin-derived antigens, such as proteolipid protein, myelin oligodendrocyte glycoprotein (MOG), or myelin basic protein (MBP), leading to an immune response targeting myelin in the CNS [12,13].