A synergistic effect was instead observed when administering HT and 3,4,-dyhydroxyphenylglycol (DHPG) (5 mg/kg/day + 1 mg/kg/day, respectively) in an experimental rat (2-month-old adult male Wistar rats) model of type 1 diabetes (T1D), where platelet aggregation, myeloperoxidase, oxidative and nitrosative stress, VCAM-1 and production of prostacyclin were significantly reduced after two months of daily administration [28]. Here, MPO is linked to type 1 diabetes mellitus.