PADI4 and androgen insensitivity syndrome: Acronyms: POC: prospective observational cohort; RCT: randomised controlled trial; AIS: acute ischemic stroke; aSAH: aneurysmal subarachnoid haemorrhage; TBI: traumatic brain injury; ab: antibody; PAD: protein-arginine deaminase; EdaB: Edaravone Dexborneol; MODS: multiorgan dysfunction syndrome.