TYR and Miyoshi myopathy: In addition, ML329, a small molecule of a specific inhibitor of microphthalmia-associated transcription factor (MITF) that regulates the expression of various pigmentation-related genes including genes encoding tyrosinase [191] and is critically involved in the pathogenesis of MM [192,193], significantly and diversely modulated the spheroid appearance and cellular metabolic functions of various MM cell lines [54].