Functional in vitro studies demonstrated the lncRNA ability to reduce the expression levels of CD40L and the transcription factor Tbet in CD4+ MG T cells and to decrease the Th1/Treg cell subset ratio, thus suggesting that IFNG-AS1 down-regulation may be involved in CD4+ T cell-mediated immune responses in MG [135]. The gene discussed is CD4; the disease is myasthenia gravis.