To investigate this further, we measured C1orf106 levels in the murine breast cancer progression series of sibling cell lines derived from a Balb/c mouse tumour [29], including the 67NR (tumourigenic but does not intravasate into blood vessels), 4T07 (metastatic to lungs but does not form metastatic outgrowths) and 4T1 cell lines (fully metastatic). Here, INAVA is linked to breast cancer.