Next, we cultivated CD8+-depleted PBMCs isolated from five patients with acute ATLL for five days and monitored transcript levels of Fra-2, HERV-H Env, and HERV-K Env, as well as Tax and HBZ (Figure 8, Supplementary Figure S3) by qRT-PCR. This evidence concerns the gene CD8A and adult T-cell leukemia/lymphoma.