Dysfunction in FGF23 signaling pathways, whether due to genetic abnormalities or other factors, can lead to systemic disorders such as XLH, the most common form of hereditary rickets, characterized by skeletal abnormalities and metabolic perturbations [5,6,7], thereby emphasizing the critical role of FGF23 in skeletal homeostasis [5]. This evidence concerns the gene FGF23 and rickets.