Apparently, distinct pathways presented by p53 are shaped by context-dependent functionally specialized p53 thresholds during various HIV infection steps: p53 might have a transient interaction with the proviral DNA synthesizing complex in the cytoplasm with subsequent enrichment for the expression of “non-canonical” error correction features, while in the nucleus, by “canonical” function, p53 participates in integration-mediated cell death through transcription-dependent pathways [104]. Here, TP53 is linked to HIV infectious disease.