TP53 and HIV infectious disease: Heterogeneous p53 responses in a target cell to a given HIV infection-mediated stress are accomplished according to the pattern of p53 expression, the precise compartmentalization of the endogenous protein, and its changes in cellular stress situations and timing of the post-translational modifications (e.g., phosphorylation, acetylation), thus eliciting selective programs of either repair of various types of DNA lesions produced during proviral DNA synthesis in the cytoplasm or triggering cell death in the nucleus.