p53 has been found to conquer HIV infection through various mechanisms: (a) p53 inhibits HIV-1 long terminal repeat (LTR) promoter activity and suppresses transcription from the integrated HIV-1 proviral genome [52]; (b) p53 suppresses Tat protein, a major transactivator of HIV-1 [53]; (c) p53 activates apoptosis of HIV-1-infected immune cells [54]; and (d) p53 and its downstream gene p21 play a significant role in the restriction of HIV-1 early stage replication in target cells [55]. Here, TP53 is linked to HIV infectious disease.