PD is predominantly an α-synucleinopathy; however, ß-amyloid pathology (plaques) and tau aggregates (neurofibrillary tangles) have also been found in about 50% of PD brains in the SN [17,55], thereby implicating a credible association between PD and tauopathology. This evidence concerns the gene MAPT and synucleinopathy.