The NFTs were usually 3R and 4R tau-positive, with no differences in the immunohistochemical profile from those in Alzheimer’s disease (AD) [18]; only in the hippocampus, NFTs showed more frequent 4R tau positivity (as, e.g., in progressive supranuclear palsy (PSP). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.