APOE and Alzheimer disease: Our hypotheses are that (i) accelerated brain aging can accurately indicate a higher risk of AD; (ii) MRI brain volume data can be used to estimate brain age; (iii) APOE4- and gender-specific training will improve predictions of brain age; and (iv) APOE4 carriers and females may experience more rapid brain volume reductions compared to APOE4 noncarriers and males.