Studies have confirmed that inhibiting the anoikis of GC cells can activate signaling pathways like JAK-STAT3, PI3K/AKT and PDGFB/PDGFRβ, thereby leading to epithelial–mesenchymal transition in tumor cells, and then induce tumor proliferation and metastasis [18,19,20,21]. This evidence concerns the gene PDGFRB and neoplasm.