These include the direct activation of the unfolded protein response and the Nrf2/Keap1 axis in an SH‐SY5Y neuroblastoma cell model, mechanisms that increase cellular resilience to oxidative stress, and dysregulated proteinogenesis seen in various models of neurotrauma.[55] The role of endothelial cells as a “lactate reservoir” that balances the energetic demands of surrounding tissue and promotes tissue regeneration and angiogenesis[56] holds promise as a therapeutic target for OCNs with beneficial implications for tissue homeostasis.[53]. This evidence concerns the gene KEAP1 and neuroblastoma.