Endothelial cell‐derived lactate (alongside astrocytes) is a crucial metabolite that supports neuronal energy metabolism in the brain, and stroke‐induced upregulation of the lactate transporter MCT4 enhances extracellular lactate export.[39] Endothelial cell upregulation of the lactate transporters MCT1 and MCT2 has also been shown to correlate with resilience to ischemia‐induced injury in the brain.[54] In addition to supporting energy metabolism, a growing body of evidence suggests a role for lactate as an activator of important homeostatic mechanisms under injury conditions. This evidence concerns the gene SLC16A7 and stroke disorder.