Specifically, the following terms were used for the database search without language and regional restrictions: “ovarian cancer” or “ovarian neoplasms” AND “deubiquitinating enzymes” or “deubiquitinases” or “ovarian tumor proteases” or “ubiquitin-specific proteases” or “ubiquitin C-terminal hydrolases” or “Josephin domain-containing proteins” or “motif interacting with Ubcontaining novel DUB family” or “JAB1/MPN/Mov34 metalloenzyme.” Other eligible studies were also reviewed from the references of each article. The gene discussed is PRSS27; the disease is ovarian neoplasm.