Functional role of TRPM2 have been reported in many diseases such as Alzheimer’s and Parkinson’s disease, ischemic stroke, neuronal cell death, neurovascular functional injury, myocardial ischemia/reperfusion injury, vascular dysfunction, pancreatic β-cell death associated with pancreatitis, acute and chronic diseases, and liver toxicity (Malko and Jiang, 2020). The gene discussed is TRPM2; the disease is ischemic stroke.