TRPM2 and early-onset autosomal dominant Alzheimer disease: Additional mechanisms such as ROS-ADPR- Poly adenosine diphosphate ribose polymerase mediated TRPM2 current in microglia thereby increase intracellular Ca2+ and thereby induce apoptosis of hippocampal pyramidal neurons in Alzheimer’s disease (Övey and Naziroğlu, 2015).