Sustained activation or dysregulation of TLR-4 contributes to inflammatory and autoimmune diseases such as Crohn’s Disease, atherosclerosis, rheumatoid arthritis, type 1 diabetes, and other neurodegenerative diseases (Takeda et al., 2003; Booth et al., 2011; Hosseini et al., 2015). Here, TLR4 is linked to rheumatoid arthritis.