Thus far, numerous roles have been proposed for the efficacy of MI in the treatment and management of cancer, which can be condensed into several categories: 1) Molecular investigations have demonstrated that MI and hexophosphate (MIP6) possess the ability to manifest anti-cancer characteristics through the direct or indirect disruption of PI3K-AKT-mTOR, MAPK, and Wnt/β-catenin pathways and modulation of insulin activity involved in cellular signals transduction, which play a crucial role in the survival, proliferation, and metastasis of cancer cells (3). Here, INS is linked to cancer.