The five most significant pathways were FGFR4 mutant receptor activation (Reactions 5/5, Entities 1/1, pValue 0.004), Defective SLC5A5 causes thyroid dyshormonogenesis 1 (Reactions 1/1, Entities 1/1, pValue 0.004), betaKlotho-mediated ligand binding (Reactions 2/2, Entities 3/, pValue 0.013), Biosynthesis of maresin-like SPMs (Reactions 1/3, Entities 1/6, pValue 0.026), and Biosynthesis of maresins (Reactions 1/5, Entities 1/8, pValue 0.034) (Figure 4C; Supplementary Table 9). This evidence concerns the gene KLB and thyroid dyshormonogenesis 1.