Figure 2B indicates that these upregulated differentially expressed genes (DEGs) may be regulated by enriched transcription factors such as SRF, LEF1, LHX3, and others. Moreover, associated diseases with these key upregulated genes, shown in Figure 2C, include erythrocytosis, adolescent idiopathic scoliosis, and several others; these conditions may increase the likelihood of HCM development and should be clinically noted. The gene discussed is LEF1; the disease is adolescent idiopathic scoliosis.