MORC3 deficiency downregulated the E-cadherin (CDH1) tumor suppressive gene and the keratin 14 (KRT14) epithelial differential marker (Figure 6B) but significantly upregulated the expression of oncogenic JUN, CCND1, CCND2, and CCN1 at the transcriptional level (Figure 6C). The gene discussed is JUN; the disease is neoplasm.