For instance, in renal clear cell carcinoma cells, the subcellular relocalization of circPPAP2B is dependent on the nondegradative ubiquitination of heterogeneous nuclear ribonucleoprotein C (HNRNPC) and the stabilization of the HNRNPC/vimentin/importin α7 ternary complex, thereby promoting cancer cell metastasis. Here, HNRNPC is linked to cancer.