METTL3 and cancer: Moreover, the functional interplay between METTL3 and p53 has been highlighted through data from the Cancer Dependency Map (DepMap), a comprehensive resource profiling hundreds of cancer cell lines for sensitivity to genetic perturbations using RNA interference (RNAi) or clustered regularly interspaced short palindromic repeats (CRISPR), providing Achilles scores that reflect gene essentiality for proliferation (46).