FOS and Anxiety: It is possible that in male LrrkG2019S mice, the unique combination of dysregulated top-down control of NAc circuitry by mPFC (Britt et al., 2012) and/or the BLA (Stuber et al., 2011) suggested by lowered cFos densities in those structures, coupled with heightened activation of NAc neurons suggested by the elevated density of cFos-labeled cells, reflects abnormal network activity that ultimately increases motivation to feed and/or blunts anxiety associated with the novel arena.