Although the prevalence of anxiety and depression in human LRRK2 mutation carriers is similar to that in idiopathic Parkinson’s (Gaig et al., 2014; San Luciano et al., 2017; Chen et al., 2020; DeBroff et al., 2023), it is less clear whether there are sex differences in psychiatric symptoms among manifesting LRRK2G2019S carriers. Here, LRRK2 is linked to depressive symptom measurement.