We found that SFTS patients over 63.5 years old, with neurological complications, serum SFTSV RNA loads more than 3,162 IU/mL, WBC more than 3.52 g/L, PLT less than 29 g/L, ALB less than 30.6 g/L, GLB more than 28.1 g/L, and cTNI more than 155.9 ng/L were more likely to develop into IPA. The gene discussed is ALB; the disease is Ito hypomelanosis.