Therefore, in the present observational study, we evaluated the time-course changes of hemodynamic/autonomic parameters, BBB permeability, microglia density, and their morphological changes, as well as Ang II availability in important autonomic nuclei, including the PVN, the nucleus of the solitary tract (NTS), and the rostral ventrolateral medulla (RVLM), during the establishment of hypertension in SHRs. Here, AGT is linked to Hypertension.