AGT and Hypertension: Because previous studies from our and other groups have linked Ang II availability with both BBB dysfunction and microglia activation (Biancardi et al., 2014; Buttler et al., 2017; Mowry et al., 2021), we also analyzed the time-course changes of Ang II density within the three autonomic nuclei during the establishment of hypertension in the same ROIs of SHRs and Wistar rats.