RYR2 and cardiac arrhythmia: Since aforementioned pioneering studies, numerous other studies have shown the ability of patient-derived iPSC-CMs in capturing specific variant-induced arrhythmias, such as LQTS, SQTS, CPVT, Timothy syndrome, and BrS, which are the results of genetic mutations in cardiac ion channels, transporters, or key cardiac proteins, such as KCNQ1 (LQTS1), KCNH2 (LQTS2), RYR2 (CPVT1), CASQ2 (CPVT2) (van Mil et al., 2018; Pourrier and Fedida, 2020).