In the previous study, intake of probiotics, Live Lactobacillus sakei K040706 is reported that its induces changed in the intestinal microbiota (increased Bacteroidetes and decreased Firmicutes), increased proliferation of T and B cell by LPS and concanavalin A, decreased the expression of pro-inflammatory mediator (such as NF-κB, signal transducer and activator of transcription 3 and toll-like receptor 4), increased NK cell activity, and alleviates DSS-induced colitis and affects the strengthening of the intestinal wall [41,42]. Here, STAT3 is linked to colitis.