The modifications consequences in the phenotype of NK cells could significantly affect their ability to combat viral infections or malignancies by reducing their cytotoxic activity (58), impairing antitumor response (59), and decreasing their capacity to release IFN-γ (60), contributing to the overall immune suppression, and may also play a role in the progression of diseases such as HBV infection. This evidence concerns the gene IFNG and viral infectious disease.