Likewise, a second study by Enette et al. with 51 participants with mild-to-moderate AD randomized to 9 weeks of moderate intensity AEx, high-intensity interval training, or educational control showed a negative effect on plasma BDNF (SMD = −1.4, 95%CI [−2.02, −0.78]) [27]. The gene discussed is BDNF; the disease is Alzheimer disease.