TP53 and B-cell chronic lymphocytic leukemia: Of note, specific alterations in the oral and intestinal microbiome of CLL patients with different status of selected prognostic features, such as Binet stage, mutation status of TP53 and IGHV, the presence of cytogenetic aberrations, and expression levels of CD38 and ZAP-70, were found (Tables SIII and SIV).