Furthermore, it is worth noting that IF could inhibit the activation of pro-inflammatory microglia after intracerebral hemorrhage (Dai et al., 2022), which is related to NLRP3 inflammasome assembly and caspase-1 activation (Ghosh et al., 2018; Dai et al., 2019), highlighting the potential of EODF in restraining the NLRP3 pyroptosis pathway. The gene discussed is NLRP3; the disease is intracerebral hemorrhage.