GZMB and cancer: The heterogeneous nature of NK‐EVs contributes to their complex killing mechanisms. Previous research has shown that these vesicles contain varying levels of cytotoxic proteins, with perforin being a predominant component. NK‐EVs have demonstrated robust cytotoxic activity against neuroblastoma and ALL cells, with granzyme B and granulysin inducing ER stress‐mediated apoptosis (Wu et al., 2019). A nuanced understanding of their biogenesis is crucial to optimizing their clinical application in cancer therapy.