Genes whose expression is significantly down-regulated within the tumour compartment of p16+/HPV+ versus p16+/HPV- and/or p16-/HPV- tumours include keratins (KRT), HIF1A, CD44, CCND1, AKT1 and CD276 (Figure 2C top left and centre panels). This evidence concerns the gene CDKN2A and neoplasm.